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. 2018 Sep 1;26(12):2823–2837. doi: 10.1016/j.ymthe.2018.08.020

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© 2018 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

The Ang-1-Tie-2 Axis Is Involved in the Proangiogenic Effect of miR-532-5p

(A) Effects of miR-532-5p inhibition on ANG-1 mRNA (i) and protein levels (ii) in human APCs. (B) Effects of miR-532-5p forced expression on ANG-1 mRNA (i) and protein levels (ii); n = 6 biological replicates per group. *p < 0.05 and **p < 0.01 versus Scrambled. (C) (i) Bar graph showing the effect of Tie-2 inhibition on the inductive effect of miR-532-5p-overexpressing APC conditioned media (CM) on HUVECs network formation. (ii) Representative Matrigel images, ×10 magnification; n = 3 biological replicates per group. *p < 0.01 versus Scrambled-transfected APC CM. Values are means ± SE.