Table 2.
CpGs surviving FDR correction in an epigenome-wide analysis (EWAS)
| Discovery | ProbeID | Gene | Position | B | p | fdr | Look up NSHD | Look up ALSPAC |
|---|---|---|---|---|---|---|---|---|
| NSHD-Parent mentally ill | cg17164016 | chr8: 110990365 | −0.067 | 8.86E−08 | 0.043 | ACE score B = -0.0026, p = 0.20 Parent physically ill B = −0.0054, p = 0.16 Parent mentally ill B = −0.067, p = 8.9e−08* Parents separated B = -0.00068, p = 0.94 Parent died B = −0.019, p = 0.006* Suboptimal maternal bonding B = 0.0061, p = 0.14 Child illness B = 0.0012, p = 0.81 Child maltreatment B = 0.0052, p = 0.46 |
ACE score B = 0.00093, p = 0.33 Parent physically ill B = -0.0018, p = 0.56 Parent mentally ill B = 0.0039, p = 0.49 Parents separated B = −0.0014, p = 0.72 Parent died B = 0.0075, p = 0.22 Suboptimal maternal bonding B = 0.0016, p = 0.65 Child illness B = 0.0073, p = 0.23 Child maltreatment B = 0.0035, p = 0.28 Sexual abuse B = 0.0044, p = 0.53 Physical abuse B = 0.0077, p = 0.33 Emotional abuse B = −0.00036, p = 0.94 Physical neglect B = 0.0049, p = 0.70 Emotional neglect B = 0.0035, p = 0.29 |
|
| NSHD-Child illness | cg10303653 | TNXB | chr6: 32049516 | −0.017 | 2.10E−08 | 0.010 | ACE score B = −0.0032, p = 0.012* Parent physically ill B = −0.0013, p = 0.59 Parent mentally ill B = 0.0057, p = 0.47 Parents separated B = −0.0033, p = 0.54 Parent died B = 0.0022, p = 0.63 Suboptimal maternal bonding B = 0.00074, p = 0.78 Child illness B = −0.017, p = 2.1e−08* Child maltreatment B = −0.00091, p = 0.84 |
ACE score B = 0.00034, p = 0.76 Parent physically ill B = 0.0021, p = 0.54 Parent mentally ill B = −0.0077, p = 0.24 Parents separated B = 0.0087, p = 0.054 Parent died B = −0.0066, p = 0.34 Suboptimal maternal bonding B = −0.00064, p = 0.88 Child illness B = 0.0057, p = 0.41 Child maltreatment B = 0.001, p = 0.78 Sexual abuse B = 0.003, p = 0.71 Physical abuse B = -0.0023, p = 0.8 Emotional abuse B = 0.00043, p = 0.94 Physical neglect B = −0.015, p = 0.31 Emotional neglect B = −0.00034, p = 0.93 |
| NSHD-Child maltreatment | cg14296561 | BIRC3 | chr11: 102203542 | −0.040 | 6.51E−09 | 0.003 | ACE score B = −0.0083, p = 4.4e−05* Parent physically ill B = −0.0062, p = 0.12 Parent mentally ill B = −0.0058, p = 0.66 Parents separated B = −0.0033, p = 0.7 0 Parent died B = −0.0072, p = 0.32 Suboptimal maternal bonding B = −0.0041, p = 0.33 Child illness B = −0.0094, p = 0.061 Child maltreatment B = -0.04, p = 6.5e−09* |
ACE score B = 0.0017, p = 0.20 Parent physically ill B = 0.0025, p = 0.55 Parent mentally ill B = −0.0019, p = 0.81 Parents separated B = 0.012, p = 0.026* Parent died B = −0.0028, p = 0.74 Suboptimal maternal bonding B = −0.0028, p = 0.59 Child illness B = 0.0043, p = 0.61 Child maltreatment B = 0.0091, p = 0.041* Sexual abuse B = 0.016, p = 0.1 0 Physical abuse B = 0.0017, p = 0.87 Emotional abuse B = 0.013, p = 0.048* Physical neglect B = −0.02, p = 0.26 Emotional neglect B = 0.0055, p = 0.25 |
*In the last two columns indicates a nominal significant association between the CpG and one of the childhood adversities in the respective cohort, NSHD or ALSPAC.
Bold in the final two columns represents the ACE to which the discovery analysis relates.