Table 3.
DMRs that replicated across cohorts
| ACE | DMR | Nr CpGs | Gene | ALSPAC (Directiona, p-value) | NSHD (Directiona, p-value) | Replicated ACEs in lookupb |
|---|---|---|---|---|---|---|
| ACE count score | chr8: 145654565-145654855 | 5 | VPS28, TONSL | ----- p = 7.5e−08* |
----- p = 1.8e−06* |
ACE count score, Parent died, Maternal bond, Child maltreatment |
| Parent mentally ill | chr12: 14720726-14721289 | 10 | PLBD1 | -++-++++++ p = 0.0058 |
+++++++++- p = 9.5e−07* |
Parent mentally ill |
| Parent mentally ill | chr1: 3104999-3105327 | 5 | PRDM16 | ----- p = 0.001 |
----- p = 7.4e−08* |
Parent mentally ill |
| Parent physically ill | chr15: 81426347-81426670 | 9 | C15orf26 | +++++++++ p = 0.011 | +++++++++ p = 7.4e–07* |
Parent mentally ill |
| Parent physically ill | chr22: 27834439-27834630 | 3 | n/a | --- p = 6.9e−06* |
--- p = 0.045 |
Parent mentally ill |
| Parent physically ill | chr8: 144120335-144120707 | 7 | C8orf31 | +++++++ p = 4.4e−06* |
+++++++ p = 0.00092 |
Parent mentally ill, Parent died |
| Parent died | chr15: 40364524-40364863 | 3 | n/a | +++ p = 6.3e−07* |
+++ p = 0.0044 |
Parent died, Parent mentally ill |
| Parent died | chr7: 24323261-24323940 | 9 | NPY | +++++++++ p = 9.2e−07* |
+++++++++ p = 0.014 |
Parent died |
| Parent died | chr2: 18766018-18766295 | 4 | NT5C1B | --- + p = 9.8e−06* | ---- p = 0.014 |
Parent died |
aDirection of effect for each individual CpG that is part of the DMR was derived from the regression coefficient in the epigenome-wide analysis for individual CpGs
bIf the DMR additionally replicated for another ACE (same direction of effect and StoufferLiptak-Kechris corrected P-value <0.05 in both ALSPAC and NSHD), the additional ACE is mentioned in this column
*DMR passed Šidák correction for multiple testing in comb-p