Table 1.

Comparison between the reproductive phenotypes of individual (CRISP1 or CRISP4) KO and DKO mice.

	Crisp1 −/−	Crisp4 −/−	DKO
Tyrosine phosphorylation	=	Affected	Affected
P4-induced acrosome reaction	Affected	Affected	Affected
Hyperactivity	Affected	=	Affected
Cumulus penetration	=	=	Affected
ZP binding	Affected	=	Affected
Fusion ability	Affected	Affected	Affected
In vitro fertilization	Affected	Affected	Affected
In vivo fertilization	=	=	Affected
Fertility	=	=	Affected

= and “affected” refer to no significant or significant differences from the corresponding WT controls, respectively.