TFF-Exosomes Are More Efficient at Delivering siRNAs to Neurons
(A) Dose-response analysis showing Huntingtin (Htt) mRNA levels in mouse primary neurons treated with 2D-UC-, 2D-TFF-, 3D-UC-, and 3D-TFF-exosomes containing the indicated doses of siRNA. Each data point represents the mean ± SEM of n = 3 experiments, two-way ANOVA. (B) Time course of fluorescence in primary neurons treated with 2D-UC-, 2D-TFF-, 3D-UC-, and 3D-TFF-exosomes containing Cy3-labeled siRNA. Each data point represents the mean ± SEM of 62–143 cells per time point, two-way ANOVA. UNT, untreated.