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. 2018 Nov 27;9:941. doi: 10.3389/fneur.2018.00941

Table 1.

Studies examining human pupil responses with silent substitution.

References Number of primaries Primary wavelengths [nm] Viewing geometry Field size Modulations [max. contrast] Background light level N observers Temporal properties Spectral sensitivities assumed
Tsujimura et al. (20) 4 470, 500, 525, 615 nm ± 20–36 nm Diffusing screen in front of integrating sphere 20° field size Melanopsin [−53%]
Luminance [−53%]
Isochromatic [−53%]
301 cd/m2 to 642 cd/m2 to 982 cd/m2 6 10 min stimuli
5 min background
Cones: CIEPO2006
Melanopsin: Dartnall nomogram at 482 nm
Assumes macular and lens filtering from CIEPO2006
Optical density 0.5
Viénot et al. (21) 5 473 ± 25 nm
511 ± 33 nm
530 ± 36 nm
595 ± 15 nm
627 ± 20 nm
Light booth with white paint Ganzfeld Melanopsin-only (cone and rod silent) [3.4%]
Multiple mixed modulations
35 cd/m2 10 Measurement after 1 min of continuous exposure Cones: CIEPO2006
Rods: V'(λ)
Melanopsin: Stockman-Sharpe shifted to peak at 482 nm; optical density 0.1; lens from Stockman & Sharpe
Tsijumura and Tokuda, (22) 4 468, 524, 599, and 633 nm (test)
466 nm,
500 nm,
517 nm,
596 nm
(background)
±15–38 nm
Diffusing screen in front of integrating sphere Annulus id 5 od 18°
Total field 23°
8% 612 cd/m2 background1,109 cd/m2 test field 6 Sinusoidal & square wave stimuli Cones: CIEPO2006, 10°
Melanopsin: Dartnall nomogram at 480 nm
Assumes macular and lens filtering from CIEPO2006
Optical density 0.4
Spitschan et al. (16) 128 n/a Viewing of surface through lens 27.5° circular, central 5° blocked S, (L+M), melanopsin, (L+M+melanopsin) [50%] 382–1,033 cd/m2 16 Sinusoidal, 0.01 – 2 Hz 10° Stockman–Sharpe/CIE cone fundamentals, melanopsin estimated by shifting Stockman-Sharpe nomogram to λmax = 480 nm, corrected for prereceptoral filtering (same as cones, optical density 0.3).
Barrionuevo et al. (23) 4 442, 516, 594, and 634 nm (one set)
466, 514, 590, and 634 nm (second set)
Ganzfeld 54° field Mixed joint modulations, no melanopsin-isolaing modulation 0.002–100 cd/m2 3 (authors) Sinusoidal, 0.5–8 Hz Smith–Pokorny cone fundamentals
Enezi et al. melanopsin function
Cao et al. (25) 5 456, 488, 540, 592, 633 Maxwellian view 30° circular, central 10.5° blocked Experiment 1: S, M, L, Rod, Melanopsin [16%]
Experiment 2: CSF
Experiment 1: 200 Photopic Td
Experiment 2: 2,000 Photopic Td
3 Sinusoidal, 1 Hz Smith–Pokorny cone fundamentals applied for the CIE 1964 10° Standard Observer
CIE 1951 scotopic luminosity function
Enezi et al. melanopsin function
Barrionuevo and Cao, (24) 5 456, 488, 540, 592, 633 Maxwellian view 30° circular, central 10.5° blocked Experiment 1: S, M, L, Rods, Melanopsin, (L+M+S) [17%], red-green [4% M,−4% L]
Experiment 2: LMS [17% each], L+M [17% each], LMS + melanopsin [16% each], Rods + melanopsin [9% each], S + melanopsin [16% each], red-green + melanopsin [2% M,−2% L, 8% melanopsin]
2–20,000 Photopic Td 3 (2 authors) Sinusoidal, 1 Hz Smith–Pokorny cone fundamentals applied for the CIE 1964 10° Standard Observer
CIE 1951 scotopic luminosity function
Enezi et al. melanopsin function
Spitschan et al. (28) 56 n/a Viewing of surface through lens 64° circular, central 5° blocked 25–400% 100–200 cd/m2 4 Tapered pulses (3 s, 14–16 s ISI) CIE 2006 parametric model
Woelders et al. (17) 5 465, 500, 515, 595 Diffusing screen in front of LEDs 24.68° horizontal, 12.13° vertical S, M, L, Melanopsin [23%] Background or average of 8.5 melanopic lux 16 Square-wave (0.25–4 Hz) α-opic lux (Lucas et al.): Govardovski nomograms, λmax from Dartnall, optical densities 0.3, 0.38, 0.38 (S, M, L)
Murray et al. (27) 4 460, 524, 590, 635 Ganzfeld Central 7° of surface covered with disk of no reflective black material. L, M, (L+M+S) [11% Weber] 17 cd/m2 5 Square-wave (1 s increment/
decrement followed by ISI of 2 s)
Stockman Sharpe cone fundamentals
Zele et al. (26) 5 456, 488, 540, 592, 633 Maxwellian view 30° circular, central 10.5° blocked Color:[7%, 22% or 24% Weber]
CFF and pupil: (L+M), S, melanopsin [17% Michelson]
2,000 photopic Td (detection thresholds and pupil)
200–5,000 Td (CFF)
4 (2 authors) Pupil: 1 Hz sinusoidal Smith–Pokorny cone fundamentals applied for the CIE 1964 108 Standard Observer CIE 1951 scotopic luminosity function Enezi et al. melanopsin function