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. 2018 Nov 27;9:708. doi: 10.3389/fendo.2018.00708

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Copyright © 2018 Krick, Helton, Hutcheson, Blumhof, Garth, Denson, Zaharias, Wickham and Barnes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FGF23 and OGA inhibition both increase IL-6 secretion in human bronchial epithelial cells. (A) Bar graphs showing transcript analysis and fold change of IL-6 and IL-8 levels in HBECs treated in the presence or absence of FGF23, TG, or OSMI-1 for 24h. (B) IL-6 and IL-8 protein amounts determined by ELISA from conditioned media of HBECs. All experiments were done in triplicate and bar graphs shown respresent the mean ± S.E.M.(^*p < 0.05; ^**p < 0.01, and ^***p < 0.001). Ctrl, Control; FGF23, fibroblast growth factor 23; TG, thiamet G (OGA inhibitor); OSMI-1, OGT inhibitor.