Table 1.

LncRNAs bind with EZH2 in lung cancer.

LncRNA	Cancer type	Expression	Bind to	Function mechanism	Associated clinical features	Associated cell process	Ref
TUG1	SCLC	up	EZH2	represses LIMK2b expression	correlates with clinical stage and shorter survival time	promotes cell growth migration and invasion, increases chemoresistance	50
TUG1	LAD	up	EZH2	represses BAX expression	associates with enhanced tumor size, degree of differentiation, lymph node metastases, distant metastasis and TNM stage.	promotes cell viability and decreases cell apoptosis	55
TUG1	NSCLC	down	EZH2, EED	represses CELF1 expression	-	inhibits cell proliferation	56
TUG1	NSCLC	down	EZH2	represses HOXB7 expression	associates with higher TNM stage and tumor size	inhibits cell proliferation	57
XIST	NSCLC	up	EZH2	represses KLF2 expression	associates with shorter survival and poorer prognosis	promotes cell proliferation, migration and invasion	61
SNHG20	NSCLC	up	EZH2	represses P21 expression	associates with advanced tumor, TNM stage and tumor size, poorer OS	promotes cell proliferation, migration and inhibits cell apoptosis	73
LINC01133	NSCLC	up	EZH2, LSD1	represses KLF2, P21 and E-cadherin transcription.	associates with poor prognosis and short survival time	increases cell proliferation, migration and invasion, decreases cell apoptosis	80
LINC00673	NSCLC	up	EZH2	silences HOXA5 expression	associates with tumor size, lymph node metastasis, TNM stage	increases cell proliferation	87
LINC00152	LAD	up	EZH2	represses IL24 expression	correlates with advanced TNM stage, larger tumor size, and lymph node metastasis, shorter survival time	promotes cell growth, suppresses cell apoptosis	98
LINC00511	NSCLC	up	EZH2	represses P57 expression	associates with oncogenesis, tumor size, metastasis, and poor prognosis	affected cell proliferation, invasiveness, metastasis, and apoptosis	102
LINC01207	LAD	up	EZH2	represses BAD expression	associates with TNM stage, advanced TNM stage and shorter survival	increases cell proliferation, decreases cell apoptosis	105
AGAP2-AS1	NSCLC	up	EZH2, LSD1	represses KLF2 and LATS2 expression	correlates with poor prognostic outcomes	increases cell proliferation, migration and invasion, and inhibits cell apoptosis.	108
HOXA11-AS	NSCLC	up	EZH2, DNMT1	represses miR-200b expression	indicates poor prognosis	promotes cell invasive abilities	121
FEZF1-AS1	NSCLC	up	EZH2, LSD1	Suppresses Wnt/β-catenin signaling	associates with lymph node metastasis, poor differentiation, and advanced TNM stage	promotes cell proliferation, invasion and EMT	129
FOXF1-AS1	NSCLC	down	EZH2	correlates with FOXF1 expression	associates with tumor migration, invasion and metastasis	inhibits cell migration and invasion by regulating EMT	136