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. 2018 Nov 27;5:316. doi: 10.3389/fmed.2018.00316

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Copyright © 2018 Bennett, Reeves, Billman and Sturmberg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Feedback loop between the somatic and central nervous system components of the inflammatory response [exogenous cytokines are typically synthetically made cytokines used as treatment for a variety of immune-related diseases like IFN-α for hepatitis C infection or IL-2 for renal cell carcinoma; adapted from Dantzer (1)].