Table 3.
Stratification analysis for association between hOGG1 genotypes and neuroblastoma susceptibility
| Variables | rs1052133 (cases/controls) |
AOR (95% CI) a | P a | Protective genotype (cases/controls) |
AOR (95% CI) a | P a | ||
|---|---|---|---|---|---|---|---|---|
| GG | GC/CC | 0 | 1-3 | |||||
| Age, month | ||||||||
| ≤18 | 65/136 | 113/294 | 0.80 (0.56-1.16) | 0.238 | 60/128 | 118/302 | 0.83 (0.57-1.21) | 0.331 |
| >18 | 132/194 | 202/452 | 0.66 (0.50-0.87) | 0.003 | 120/183 | 214/463 | 0.71 (0.53-0.93) | 0.015 |
| Gender | ||||||||
| Females | 81/149 | 137/305 | 0.83 (0.59-1.16) | 0.279 | 77/139 | 141/315 | 0.81 (0.58-1.14) | 0.230 |
| Males | 116/181 | 178/441 | 0.63 (0.47-0.85) | 0.002 | 103/172 | 191/450 | 0.71 (0.53-0.96) | 0.026 |
| Sites of origin | ||||||||
| Adrenal gland | 68/330 | 128/746 | 0.84 (0.61-1.15) | 0.275 | 66/311 | 130/765 | 0.81 (0.58-1.12) | 0.192 |
| Retroperitoneal | 55/330 | 73/746 | 0.58 (0.40-0.85) | 0.005 | 50/311 | 78/765 | 0.63 (0.43-0.92) | 0.017 |
| Mediastinum | 54/330 | 81/746 | 0.66 (0.46-0.96) | 0.029 | 46/311 | 89/765 | 0.79 (0.54-1.15) | 0.213 |
| Others | 15/330 | 30/746 | 0.88 (0.47-1.67) | 0.703 | 13/311 | 32/765 | 1.00 (0.52-1.93) | 0.991 |
| Clinical stages | ||||||||
| I+II+4s | 106/330 | 153/746 | 0.64 (0.48-0.85) | 0.002 | 94/311 | 165/765 | 0.71 (0.54-0.95) | 0.020 |
| III+IV | 83/330 | 150/746 | 0.81 (0.60-1.09) | 0.155 | 79/311 | 154/765 | 0.80 (0.59-1.08) | 0.145 |
AOR, Adjusted odds ratio; CI, confidence interval.
a Adjusted for age and gender, without the corresponding factor.