Table 6.

Top 15 hub genes identified in the PPI network.

Upregulated miRNAs			Downregulated miRNAs
Gene symbol	Degree		Gene symbol	Degree
PHLPP2	80		VEGFA	58
APP	45		NOTCH1	48
BCL2	44		BCL2	46
RB1	44		FOS	46
CCND1	41		HDAC3	37
SMAD4	38		PPP3CA	36
RBBP7	37		SIRT1	36
ESR1	36		SP1	34
KAT2B	34		CFTR	33
NEDD4L	34		KDR	32
CUL3	32		MYB	31
ATG7	32		ACTR1A	29
CLTC	32		PRKCA	28
ITCH	31		VAMP2	27
UBE2B	31		DICER1	26

PPI protein-protein interaction