Table 2.
The correlation of PD-L1 expression with MSI status, PD-1 expression, CD4 and CD8 density in colorectal cancer.
| Characteristics | PD-L1 expression, n(%) | P value | ||
|---|---|---|---|---|
| Absent and Low | Moderate | High | ||
| MSI | 0.01 | |||
| dMMR | 64 (59.8) | 15 (14.0) | 28 (26.2) | |
| pMMR | 238 (75.6) | 31 (9.8) | 46 (14.6) | |
| PD-1 expression | < 0.001 | |||
| Absent and Low | 290 (74.0) | 43 (11.0) | 59 (15.1) | |
| Moderate | 5 (50.0) | 1 (10.0) | 4 (40.0) | |
| High | 7 (35.0) | 2 (10.0) | 11 (55.0) | |
| CD4 density | < 0.001 | |||
| Absent and Low | 247 (77.9) | 29 (9.1) | 41 (12.9) | |
| Moderate | 47 (56.0) | 16 (19.0) | 21 (25.0) | |
| High | 8 (38.1) | 1 (4.8) | 12 (57.1) | |
| CD8 density | < 0.001 | |||
| Absent and Low | 265 (80.8) | 28 (8.5) | 35 (10.7) | |
| Moderate | 34 (47.9) | 15 (21.1) | 22 (31.0) | |
| High | 3 (13.0) | 3 (13.0) | 17 (73.9) | |
Abbreviations: PD-L1, programmed death ligand 1; CD4, cluster of differentiation 4; CD8, cluster of differentiation 8; MSI, microsatellite instability; dMMR, DNA mismatch repair deficiency; pMMR, DNA mismatch repair proficiency.