Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 31;9(23):4449–4462. doi: 10.7150/jca.25926

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Ivyspring International Publisher

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.

PMC Copyright notice

TNC promotes pancreatic cancer cell proliferation via the modulation of AKT/FOXO1 signals. (A) The flow cytometry cell cycle analyses of PANC-1 cell growth were evaluated after treatment with TNC or TNC+LY294002/siAKT/FOXO1. (B) Western blot analysis was performed to determine the expression of AKT, pAKT, CDK4 and cyclin D1 in PANC-1 cells after the indicated treatment. (C) PANC-1 cells were preincubated with LY294002 or DMSO for 1 h before exogenous TNC stimulation. Cells were harvested at the indicated time, and the levels of phosphorylated AKT, FOXO1 and the subcellular expression of pFOXO1 in the cell nuclear and cytoplasmic fractions were analysed by western blot. Data represent the mean ± the s.d. (n = 3, *P < 0.05).