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. 2018 Nov 27;9:2927. doi: 10.3389/fmicb.2018.02927

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Copyright © 2018 Seijsing, Sobieraj, Keller, Shen, Zinkernagel, Loessner and Schmelcher.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Normalized mean serum concentration-time profiles and biodistribution in murine liver and kidneys of CSL[Eu] and C[ABD]SL[Eu]. C57BL/6 wild-type mice were injected intravenously with the europium (Eu)-labeled protein constructs, blood samples were drawn at predetermined time points, and organs were harvested after euthanasia at 144 and 216 h post-injection. Blood and organs were analyzed for Eu concentration and data are shown as mean concentrations with standard errors of the mean from a total of four mice per group. (A) Normalized concentrations of Eu-labeled endolysin constructs in the murine blood at various time points from 0 to 144 h post-injection. (B) Eu concentration of the control CSL[Eu] and the ABD-containing C[ABD]SL[Eu] in the liver and kidneys 144 and 216 h post-injection.