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. 2018 Nov 27;11:437. doi: 10.3389/fnmol.2018.00437

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Copyright © 2018 Zhang, Xia, Luo, Huang, Wang, Shentu, Mahaman, Huang, Ke, Wang, Liu, Wang, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CPPs rescued hTau-induced cognitive impairments. hTau-overexpressed mice were treated with CPPs for 1 month. NOR experiment (A) was performed to assess the mice behavior. (B) Recognition index between object A and B. After 1 h, object C were used instead of object B. Recognition index were recorded in 5 min (C). After 24 h, object D were used instead of object C. Recognition index between object A and D were detected (D). (E) Discrimination index of each group. (F,G) Morris water maze (MWM) test were performed. (H) Escape latency of MWM. (I) The swimming time in the target quadrant in 1 min after removing the platform. (J) The crossings in the target quadrant in 1 min after removing the platform. (K) The mean swimming speed of each group. ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001 vs. WT mice, #P < 0.05, ###P < 0.001 vs. hTau-overexpressed mice without CPPs treatment, n = 5.