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. 2018 Nov 27;11:437. doi: 10.3389/fnmol.2018.00437

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Copyright © 2018 Zhang, Xia, Luo, Huang, Wang, Shentu, Mahaman, Huang, Ke, Wang, Liu, Wang, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CPPs enhanced synaptic plasticity and functions. (A) Brain slice with MED64 array chamber in the warm artificial cerebral spinal fluid (ACSF) LTP was induced by applying three trains of high-frequency stimulation (HFS; 100 Hz, 1-s duration). (B) The traces are average fEPSPs before (blue) and after (red) LTP induction. (C) The slope of fEPSP was normalized by the baseline after HFS recorded on hippocampal slices after 1 month treated with CPPs in AVV-hTau injected mice. (D) Quantitative analyses for fEPSPs relative to baseline after high-frequency stimulation (HFS; 100 Hz, 1-s duration). ^∗∗P < 0.01, ^∗∗∗P < 0.001 vs. WT mice, ##P < 0.01 vs. hTau-overexpressed mice without CPPs treatment, n = 3.