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. 2018 Nov 27;9:2376. doi: 10.3389/fpsyg.2018.02376

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Copyright © 2018 McGregor, Crosson, Krishnamurthy, Krishnamurthy, Hortman, Gopinath, Mammino, Omar and Nocera.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The AE-BAL group t-test of Z(CC)_DIFF seeded from L-M1 shows aDMN connectivity differences, indicating that the 12-week aerobic spin intervention was able to significantly L-M1 to aDMN connectivity in the AE group (p = 0.01, cluster size = 50). To further understand the relationship between individual subject response to the intervention, the % Time in Target HR Zone was correlated with Z(CC)_DIFF seeded from L-M1 on a voxel-wise basis as described in Equation 4. The regression analysis also shows exercise induced changes in L-M1 to aDMN connectivity, along with L-M1 to pDMN, and L-M1 to L-PMd connectivity (p = 0.01, cluster size = 50). The plots show the average Z(CC)_DIFF from the extracted ROI is predicted significantly by % Time in Target HR Zone. Closed circles = AE; Open circles = BAL.