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. 2018 Nov 27;9:2376. doi: 10.3389/fpsyg.2018.02376

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Copyright © 2018 McGregor, Crosson, Krishnamurthy, Krishnamurthy, Hortman, Gopinath, Mammino, Omar and Nocera.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The AE-BAL group t-test of Z(CC)_DIFF seeded from aDMN shows L-M1 connectivity differences, which is expected based on the L-M1 seed results. However, when taking into account the individual subject response to the intervention by regressing Z(CC)_DIFF with % Time in Target HR Zone, both aDMN to L-M1 and aDMN to R-M1 connectivity relationships became apparent. A bilateral aDMN to Precuneus connectivity relationship also emerged with the regression analysis. These results indicate the importance of taking into account the individual subject response to the intervention to ascertain exercise-induced brain changes.