Table 1.
Strategy | I | II | III | IV |
---|---|---|---|---|
Status of BNB | Barrier breached | Barrier intact | Barrier intact | Barrier intact |
Clinical example | Peripheral nerve trauma | Anesthesia, neuropathic pain | Gene therapy | Inflamed vasculature |
Mechanism of access | Direct placement | Diffusion across BNB, with or without disruption | Retrograde axonal transport | Transendothelial migration |
The underlying status of the blood nerve barrier (BNB) and clinical application dictate the mechanism of access to the endoneurium.