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. 2018 Nov 27;9:712. doi: 10.3389/fendo.2018.00712

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Copyright © Lee, Jacobs and Lee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multi-dimensional aspects of interrelationships between persistent organic pollutants (POPs) and adipose tissue. Even though POPs have been evaluated as a new risk factor for type 2 diabetes (T2D), independent of obesity, the role of POPs should be evaluated together with obesity due to their innate interrelationship. POPs are involved in key mechanisms linking obesity and T2D such as pro-inflammatory adipose tissue and ectopic fat accumulation (Dimensions 1 and 2). In addition, POPs can explain puzzling findings about obesity, which suggest beneficial effects of adipose tissue (Dimensions 3 and 4). Finally, obesogenic effects of chemicals may not always be harmful (Dimension 5). All these issues are critical to understand the role of POPs in the development of T2D.