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Effect of spinal 5-HT2A receptor inhibition on stimulus-evoked firing in the VPL of sham rats. WDR neuronal responses to punctate mechanical (A), heat (B), cold (C), and dynamic brush (D) stimuli, prior to and following spinal administration of 50 and 100 μg ketanserin. Histogram traces represent typical single unit responses. Data represent mean ± 95% CI, n = 12 neurones from 8 rats. (Ac – acetone, Ec – ethyl chloride).
