Table 3.
MIC and IC50 data for compounds 1–4 against methicillin-resistant S. aureus (MRSA USA300 LAC strain AH1263) [20] relative to vehicle control measured turbidimetrically by OD600. Presented data were calculated using four-parameter logistic curves of triplicate data.
| Compound | MICa | IC50 |
|---|---|---|
| 1 | 4.6 µM | 2.0 µM |
| 2 | 4.0 µM | 2.3 µM |
| 3 | -- | -- |
| 4 | -- | 168 µM |
a
The MIC value expressed is likely higher than the actual MIC value, which lies somewhere between the lowest tested concentration that inhibited bacterial growth and the highest tested concentration that did not completely inhibit bacterial growth [27].