Fig. 4.
Coapplication of GABA with an allosteric or orthosteric agonist. The experimental and predicted Popen values are given for combinations of GABA with propofol (PRO), pentobarbital (PEB), alfaxalone (ALF), P4S, or β-alanine (β-Ala). The open circles show experimental data from each cell separately. The open triangles and squares show predictions based on models assuming distinct or same sites for the paired compounds. The filled symbols and error bars shown mean ± S.D. for each condition. The data and results of statistical analyses are summarized in Table 2. Prediction with the same site model was not done for the GABA + PRO combination because of a difference in the number of postulated binding sites.