Fig. 6.
Coapplication of allosteric agonists. The experimental and predicted Popen values are given for the steroid combinations of alfaxalone (ALF) + 3α5αP, 3α5αP + 3α5βP, 3α5βP + ent-3α5βP, and alfaxalone + etiocholanolone (Etio), and the combinations of alfaxalone with propofol (PRO) or pentobarbital (PEB). The open circles show experimental data from each cell separately. The open triangles and squares show predictions based on models assuming distinct or same sites for the paired compounds. The filled symbols and error bars show mean ± S.D. for each condition. The experimental conditions, data, and results of statistical analyses are summarized in Table 2. Prediction with the same site model was not done for the ALF + PRO combination because of a difference in the number of postulated binding sites.