. 2019 Jan;95(1):70–81. doi: 10.1124/mol.118.113464

TABLE 3.

Effects of combinations of propofol and pentobarbital on open probability

The columns give the type of receptor, the total number of propofol sites, the number of sites that can bind either propofol or pentobarbital, the open probabilities in the presence of propofol, pentobarbital, or propofol + pentobarbital, the open probability calculated for the specified number of shared sites, and the open probability calculated assuming that propofol and pentobarbital bind to distinct sites. The number of cells was seven for wild-type concatemers and six for the mutant receptor. The model with shared sites was more likely—by >10⁵- and 10⁴-fold, respectively—than the model with distinct sites to describe the data for the wild-type concatemeric and mutant receptors. The Δ values (see Materials and Methods) for the lower ranked model were 27 and 19 for the wild-type and mutant concatemeric receptors, respectively.

Receptor	N_PRO	N_{PRO or PEB}	P_open,PRO	P_open,PEB	P_open,PRO+PEB	Predicted P_open
Receptor	N_PRO	N_{PRO or PEB}	P_open,PRO	P_open,PEB	P_open,PRO+PEB	Shared Site	Distinct Site
βαγ + βα	6	2	0.023 ± 0.015	0.023 ± 0.019	0.29 ± 0.17	0.26 ± 0.18	0.67 ± 0.25
β(Y143W+M286W)αγ + β(Y143W+M286W)α	2	2	0.27 ± 0.06	0.27 ± 0.04	0.36 ± 0.06	0.37 ± 0.06	0.49 ± 0.10

PEB, pentobarbital; PRO, propofol.