Table 4.

Association of Lp(a) with CVD using continuous terms (per 10 mg/dL) or categories, adjusting for RRS or ACC/AHA covariables in the WHI sample.^*

Variable	Subcohort	Cases	Beta	P	HR	CI
RRS Vars +
Lp(a) (if > 10 and TC<220)	881	820	−0.0313	0.15	0.969	0.928–1.012
Lp(a) (if > 10 and TC≥220)	1108	995	0.0407	0.007	1.042	1.011–1.073
Lp(a) Categories for TC≥220
Ref	1322	1191	0	-	1.00	-
10-<25	317	257	0.04166	0.73	1.043	0.825–1.318
25-<50	147	151	0.36133	0.016	1.435	1.070–1.925
50-<75	101	102	0.17286	0.376	1.189	0.811–1.743
75+	102	114	0.42690	0.014	1.532	1.091–2.152
ACC/AHA Vars +
Lp(a) (if > 10 and TC<220)	881	820	−0.0300	0.17	0.970	0.930–1.013
Lp(a) (if > 10 and TC≥220)	1108	995	0.0419	0.0051	1.043	1.013–1.074
Lp(a) Categories for TC≥220
Ref	1322	1191	0	-	1.00	-
10-<25	317	257	0.01801	0.88	1.018	0.809–1.282
25-<50	147	151	0.31708	0.034	1.373	1.025–1.840
50-<75	101	102	0.19965	0.26	1.221	0.860–1.734
75+	102	114	0.38929	0.022	1.476	1.057–2.061
RRS Model A Variables +
Lp(a) (if >10 and ApoB<100)	1073	929	−0.0200	0.31	0.980	0.943–1.019
Lp(a) (if >10 and ApoB≥100)	916	885	0.0381	0.015	1.039	1.007–1.071
Lp(a) Categories for ApoB≥100
Ref†	1429	1266	0	-	1.00	-
10-<25	259	210	−0.06795	0.60	0.934	0.727–1.201
25-<50	123	144	0.24528	0.13	1.278	0.933–1.750
50-<75	87	90	0.10699	0.60	1.113	0.749–1.653
75+	91	104	0.36637	0.041	1.442	1.014–2.051

^*HR=hazard ratio; CI=confidence interval; Ref = those with TC<220 or Lp(a)<10.

^†Ref = those with ApoB<100 or Lp(a)<10.