Table 2.

Cardiac dysfunction

Parameter	Control	Adenine
No.	6	10
Ejection fraction, %	72.84 ± 1.425	65.14 ± 0.8203 ***
Fractional shortening, %	41.17 ± 1.092	35.41 ± 0.6011 ***
Fractional area change, %	49.82 ± 0.6524	42.80 ± 1.149 ***
LVID, mm	3.832 ± 0.1192	4.257 ± 0.04804 *
IVS, mm	0.9647 ± 0.08316	1.039 ± 0.04658
Heart/bodyweight ratio	0.004341 ± 0.0001352	0.006031 ± 0.0001553 ***

Control group (n = 6) received standard chow for 20 weeks. Adenine treated group (n = 10) received standard chow with the addition of 0.15% adenine for 20 weeks. Echocardiography showed slight, but significant, reductions in percentage of ejection fraction, fractional shortening, and fractional area change (P < 0.0001). There was an increase in left ventricular dimensions (left ventricular internal diastolic dimension (LVID) and left ventricular end Diastolic volume; P < 0.05), and a significantly greater heart weight-to body weight ratio (P < 0.0001), mean ± SEM unpaired t- test

***P < 0.0001

*P < 0.05