Table 2.
The SMICs of amphotericin B and caspofungin in C. albicans biofilms
| Farnesol (μM) | amphotericin B(μg/ml) | caspofungin(μg/ml) | ||||
|---|---|---|---|---|---|---|
| CAI4-pCaEXP | CYR1OE | PDE2OE | CAI4-pCaEXP | CYR1OE | PDE2OE | |
| 6 h | ||||||
| 0 | 1 | 4 | 4 | 0.125 | 0.125 | 8 |
| 50 | 1 | 4 | 4 | 0.125 | 0.125 | 8 |
| 100 | 0.5 | 2 | 4 | 0.0625 | 0.0625 | 8 |
| 200 | 1 | 4 | 2 | 0.0625 | 0.0625 | 0.625 |
| 300 | 1 | 4 | 1 | 0.0625 | 0.0625 | 0.25 |
| 600 | 1 | 4 | 1 | 0.0625 | 0.0625 | 0.25 |
| 1200 | 1 | 2 | 1 | 0.0625 | 0.125 | 0.125 |
| 12 h | ||||||
| 0 | 0.5 | 8 | 4 | > 8 | > 8 | 0.0625 |
| 50 | 0.5 | 4 | 4 | > 8 | 8 | 0.0625 |
| 100 | 0.5 | 4 | 2 | > 8 | > 8 | 0.0625 |
| 200 | 0.5 | 4 | 2 | 0.25 | 8 | 0.0625 |
| 300 | 1 | 4 | 2 | 0.25 | 0.0625 | 0.0625 |
| 600 | 1 | 8 | 1 | 0.25 | 0.0625 | 0.0625 |
| 1200 | 16 | 8 | 2 | 0.0625 | 0.125 | 0.0625 |
| 24 h | ||||||
| 0 | 1 | > 16 | 1 | > 8 | > 8 | > 8 |
| 50 | 1 | 16 | 1 | > 8 | 8 | > 8 |
| 100 | 1 | 16 | 1 | > 8 | 0.125 | > 8 |
| 200 | 0.5 | 8 | 1 | > 8 | 0.0625 | 0.25 |
| 300 | 1 | 8 | 1 | > 8 | 0.0625 | 0.0625 |
| 600 | 0.125 | 8 | 1 | 2 | 0.0625 | 0.125 |
| 1200 | 0.125 | 8 | 1 | > 8 | 0.0625 | 0.125 |
| 36 h | ||||||
| 0 | 0.25 | 16 | 16 | > 8 | > 8 | > 8 |
| 50 | 0.25 | 16 | 16 | 4 | 1 | > 8 |
| 100 | 2 | 8 | 8 | 1 | 0.5 | > 8 |
| 200 | 0.125 | 4 | 4 | 0.25 | 0.5 | 0.125 |
| 300 | 0.125 | 4 | 4 | 0.125 | 0.5 | 0.125 |
| 600 | 0.25 | 4 | 2 | 0.0625 | 0.5 | 0.25 |
| 1200 | 0.125 | 4 | 2 | 4 | 0.5 | 0.5 |