Table 3.
The SMICs of itraconazole and terbinafine in C. albicans biofilms
| Farnesol (μM) | itraconazole(μg/ml) | terbinafine(μg/ml) | ||||
|---|---|---|---|---|---|---|
| CAI4-pCaEXP | CYR1OE | PDE2OE | CAI4-pCaEXP | CYR1OE | PDE2OE | |
| 6 h | ||||||
| 0 | > 16 | 0.0625 | 0.3125 | > 256 | > 256 | > 256 |
| 50 | > 16 | 0.0625 | 0.0625 | > 256 | > 256 | > 256 |
| 100 | > 16 | 0.125 | 0.0625 | > 256 | > 256 | > 256 |
| 200 | > 16 | 0.125 | > 16 | > 256 | 2 | 4 |
| 300 | > 16 | 0.125 | > 16 | > 256 | 2 | 2 |
| 600 | > 16 | 0.125 | > 16 | > 256 | 4 | 8 |
| 1200 | > 16 | 0.125 | > 16 | > 256 | 16 | 4 |
| 12 h | ||||||
| 0 | > 16 | > 16 | > 16 | > 256 | > 256 | > 256 |
| 50 | > 16 | > 16 | > 16 | > 256 | > 256 | > 256 |
| 100 | > 16 | > 16 | > 16 | > 256 | > 256 | > 256 |
| 200 | > 16 | 0.5 | 0.125 | > 256 | > 256 | > 256 |
| 300 | > 16 | 0.5 | 0.125 | > 256 | 2 | 4 |
| 600 | > 16 | 0.5 | 0.125 | > 256 | 2 | 4 |
| 1200 | 1 | 1 | 1 | > 256 | 4 | 32 |
| 24 h | ||||||
| 0 | > 16 | > 16 | > 16 | > 256 | > 256 | > 256 |
| 50 | > 16 | > 16 | > 16 | > 256 | > 256 | > 256 |
| 100 | > 16 | > 16 | > 16 | > 256 | > 256 | > 256 |
| 200 | > 16 | 16 | 2 | > 256 | 1 | 1 |
| 300 | > 16 | 0.25 | 0.125 | > 256 | 2 | 2 |
| 600 | > 16 | 0.25 | 0.25 | > 256 | > 256 | > 256 |
| 1200 | > 16 | 0.5 | 0.5 | > 256 | > 256 | > 256 |
| 36 h | ||||||
| 0 | > 16 | > 16 | > 16 | > 256 | > 256 | > 256 |
| 50 | > 16 | > 16 | > 16 | > 256 | > 256 | > 256 |
| 100 | > 16 | > 16 | > 16 | > 256 | > 256 | > 256 |
| 200 | 0.125 | > 16 | > 16 | > 256 | > 256 | > 256 |
| 300 | 0.5 | > 16 | 16 | > 256 | > 256 | > 256 |
| 600 | 1 | > 16 | 2 | > 256 | > 256 | > 256 |
| 1200 | 2 | > 16 | 4 | > 256 | > 256 | > 256 |