Table 1.
Mouse longevity genes not directly related to GH signaling.
| Gene | Genetic modification that extends life | Reference |
|---|---|---|
| Insulin receptor (in adipose tissue; FIRKO) | KO | Bluher et al., 2003 |
| Insulin receptor substrate 1 (Irs1) | KO | Selman et al., 2008 |
| Insulin receptor substrate 2 (Irs2) | KO | Taguchi et al., 2007 |
| S6K1 protein kinase | KO | Selman et al., 2009 |
| Catalase (mitochondrial over expression) | Tg | Schriner et al., 2005 |
| Klotho (transgenic overexpression) | Tg | Kurosu et al., 2005 |
| Adenylyl cyclase type 5 (AC5) | KO | Vatner et al., 2015 |
| Insulin (Ins1-/- Ins2+/-) | KO | Templeman et al., 2017 |
| Regulator of G protein signaling 14 Rgs14 | KO | Vatner et al., 2018 |
| Beclin J-BCL2 complex | Mutation knock-in | Fernández et al., 2018 |
KO, targeted disruption (“knockout” KO) of the gene; Tg, transgenic expression.