Table 1.

Motor behavior and cerebellar electrophysiological phenotypes in murine models of Alzheimer’s disease (AD).

Mouse model	Motor deficits	Cerebellar electrophysiological changes	References
APPswe/PSEN1-L166P (Radde et al., 2006)	At pre-plaque stage: No motor coordination and motor learning deficits on balance beam test and accelerated rotarod test No gait impairment on footprinting test	At pre-plaque stage: ↓ PC excitability unaffected PF-PC basal transmission unaffected CF-PC basal transmission ↓ CF-PC paired-pulse depression loss of large mIPSCs	Hoxha et al. (2012)
APPswe/PSEN1dE9 (Jankowsky et al., 2004)	At pre-plaque stage: Motor coordination deficits on rotarod test Motor learning deficits on the ErasmusLadder task	At pre-plaque stage: unaffected PF-PC basal transmission ↓ LTD at PF-PC synapse	Kuwabara et al. (2014)
		At post-plaque stage: ↓ simple spike firing unaffected complex spike firing	Sepulveda-Falla et al. (2014)
TgCRND8 (Chishti et al., 2001)	At pre-plaque stage: Motor coordination deficits on balance beam test Gait impairment on footprinting test No motor learning deficits on the accelerated rotarod test	At pre-plaque stage: unaffected PF-PC basal transmission ↓ LTD at PF-PC synapse impaired noradrenergic modulation of PF-PC synapse	Russo et al. (2018)
APP23 (Sturchler-Pierrat et al., 1997)	At pre-plaque stage: Motor coordination deficits on rotarod test	n.d.	Van Dam et al. (2003)
5×FAD (Oakley et al., 2006)	At post-plaque stage: Motor coordination deficits on balance beam test Motor learning deficits on the accelerated rotarod test Gait impairment on footprinting test	n.d.	Ewers et al. (2006) and O’Leary et al. (2018)
Tg2576 (Hsiao et al., 1996)	At pre-plaque stage: No motor learning deficits on the accelerated rotarod test	n.d.	Dineley et al. (2002)

Abbreviations: n.d., not determined; PC, Purkinje cell; PF, parallel fiber; CF, climbing fiber; LTD, long term depression.