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. 2018 Oct 24;23(11):2750. doi: 10.3390/molecules23112750

Figure 2.

Figure 2

Biological activities of FTY720 derivatives; (A) HT-29 cells were treated with compounds 2–10 at 40 µM for 24 h (FTY720 (1) 20 µM), and cell viability was measured by EZ-CYTOX kit (n = 8). Cytotoxic effects of compound 7 and FTY720 in different cancer cells. The 3000 cells/well were plated in a 96-well plate and treated with compound 7 in the concentrations of 2.5, 5, 10, 20 or 40 μM, and FTY720 20 μM in HT-29 cells (B), HCT-116 cells (C), AGS cells (D), and PC-3 cells (E); (F) annexin V-FITC assays were performed in HT-29 cells. Data are means ± SD from three independent experiments. * p < 0.05, ** p < 0.01 compared with control cells.