Scheme 1.
Synthesis of FTY720 derivatives 2–10. Reagents and conditions; (a) heptanoic acid, EDCI, DMAP, CH2Cl2, rt, 12 h; (b) TsCl, NEt3, CH2Cl2, rt, 6 h; (c) amines, MeCN, 50 °C, 12 h.
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