Table 2.
Glycogen synthase kinase 3β inhibitory potentials of polar compounds from water extract of Salvia miltiorrhiza.
| Sample | IC50 (Mean ± SEM) a | K i c | Inhibition Mode |
|---|---|---|---|
| Salvianolic acid A | 30.21 ± 3.14 f | - | - |
| Salvianolic acid B | 6.97 ± 0.96 g | 5.44/6.32 | Competitive |
| Salvianolic acid C | 31.82 ± 2.08 f | - | - |
| Caffeic acid | 425.01 ± 7.61 d | - | - |
| Rosmarinic acid | 135.35 ± 4.69 e | - | - |
| Magnesium lithospermate B | 33.07 ± 3.88 f | - | - |
| Luteolin b | 2.18 ± 0.13 g | - | - |
| AR-A014418 b | 0.10 | 0.03 | ATP-competitive [30] |
| Alsterpaullone b | 0.004 | - | ATP-competitive [31] |
| Indirubin b | 0.60 | - | ATP-competitive [32] |
a The 50% inhibitory concentrations (IC50, μM) are expressed as the mean ± SEM of triplicate experiments. b Used as a reference control. c Ki values for ATP-competitive and muscle glycogen synthase (GSM)-competitive inhibition, respectively. d–g Mean with different letters are significantly different with Duncan’s test at p < 0.05.