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. 2018 Nov 1;23(11):2839. doi: 10.3390/molecules23112839

Figure 5.

Figure 5

Cells overexpressing E46K mutant α-syn exhibited enhanced vulnerability to apoptosis insults. (A) Morphological changes of PC12 cells overexpressing WT and E46K mutant α-syn were observed. The arrowhead indicated abnormal cells. Scale bar: 50 μm. (B) PC12 cells overexpressing WT and E46K mutant α-syn were treated with 10 μM Rot for 24 h and cell viability was assessed by the MTT assay. (C) PC12 cells overexpressing WT and E46K mutant α-syn were treated with serum-free medium for 24 h and cell viability was assessed by the MTT assay. Data were expressed as means ± SD for three independent experiments performed in triplicate. * p < 0.05 when compared with the WT group.