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The detection of BrdU using DNase I and exonuclease III. Examples of microscopic images of cell nuclei labeled for 5 min with BrdU and fixed with formaldehyde. The DNA was labeled by DAPI. The scale bar—50 μm. Adapted with permission from Ligasová et al., 2017, Looking for ugly ducklings: The role of the stability of the BrdU-antibody complex and the improved method of the detection of DNA replication. PLoS ONE 12(3): e0174893 [47].
