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. 2018 Nov 8;23(11):2914. doi: 10.3390/molecules23112914

Scheme 4.

Scheme 4

Synthesis of NO donor/spirolactone-type diterpenoid hybrids 75af and 76af. Reagents and conditions: (a) ClCH2COOH, NaOH (aq), 60 °C; (b) 30% H2O2, AcOH, rt; (c) fuming HNO3, AcOH, 60 °C; (d) corresponding diol, NaOH (aq), THF, rt; (e) triethylamine, succinic anhydride, DMAP, rt; and (f) 74ai, EDCI, DMAP, rt.