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. 2018 Nov 8;23(11):2914. doi: 10.3390/molecules23112914

Scheme 6.

Scheme 6

Synthesis of spirolactone-type 6,7-seco-ent-kauranoid derivatives (9497). Reagents and conditions: (a) 10% HCl, THF (v/v, 1:1), rt; (b) Pb(OAc)4, K2CO3, THF, 0 °C; and (c) EDCI, DMAP, DCM, rt.