Table 1.
MIC50, cytotoxicity and selectivity index (SI) of compounds 1–14.a
| Compound | MIC50 (µg/mL) b,c | CC50 (µg/mL) d | ||||
|---|---|---|---|---|---|---|
| S. aureus | S. aureus MRSA | S. epidermis | S. mutants | E. faecalis | ||
| TCC | 0.5 (29) | 0.5 (29) | 0.5 (29) | NA e | NA | 14.5 |
| TFC | 0.5 (27.4) | 0.5 (27.4) | 0.5 (27.4) | NA | >20 | 13.7 |
| 1 | 1 (4.8) | 1 (4.8) | 1 (4.8) | 5 | 1 (4.8) | 4.8 |
| 2 | 1 (4.8) | 1 (4.8) | 1 (4.8) | 5 | 1 (4.8) | 4.8 |
| 3 | 0.5 (110) | 0.5 (110) | 1 (55) | NA | NA | 55 |
| 4 | 0.5 (56) | 0.5 (56) | 0.5 (56) | NA | 5 | 28 |
| 5 | 0.5 (10.2) | 0.5 (10.2) | 0.5 (10.2) | 0.5 (10.2) | 0.5 (10.2) | 5.6 |
| 6 | 0.5 (8.4) | 0.5 (8.4) | 0.5 (8.4) | 0.5 (8.4) | 0.5 (8.4) | 4.2 |
| 7 | 0.5 (26.2) | 0.5 (26.2) | 0.5 (26.2) | >20 | 5 | 13.1 |
| 8 | 0.5 (26) | 0.5 (26) | 0.5 (26) | NA | 0.5 (26) | 13 |
| 9 | 0.5 (25) | 0.5 (25) | 0.5 (25) | 0.5 (25) | 0.5 (25) | 12.5 |
| 10 | 0.05 (412) | 0.05 (412) | 0.5 (41.2) | 0.5 (41.2) | 0.5 (41.2) | 20.6 |
| 11 | 0.5 (67) | 0.5 (67) | 0.5 (67) | 0.5 (67) | >10 | 33.5 |
| 12 | 0.5 (67.6) | 0.3 (112.7) | 0.5 (67.6) | 2 (16.9) | 2 (16.9) | 33.8 |
| 13 | 0.5 (49.2) | 0.5 (49.2) | 0.5 (49.2) | 0.5 (49.2) | 0.5 (49.2) | 24.6 |
| 14 | 0.5 (20) | 0.5 (20) | 0.5 (20) | 0.5 (20) | 0.5 (20) | 10 |
a For each tested compound, MIC50 values are represented in the first row, whereas SI values are indicated in brackets. b MIC50 values were determined against the following Gram-positive bacterial strains: Staphylococcus aureus (ATCC 12600); Staphylococcus aureus methyciline resistant; Staphylococcus epidermis (ATCC 1798); Streptococcus mutants (ATCC 25175); Enterococcus faecalis (ATCC 19433). c All the compounds were inactive against two Gram-negative bacterial strains: Escherichia coli (ATCC 700926) and Pseudomonas aeruginosa (ATCC 15692). d CC50 values were determined against murine macrophages cells (J-774A.1). e NA, no antibacterial activity detected (MIC50 > 100 µg/mL).