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. 2018 Oct 25;41(1):43–56. doi: 10.3892/or.2018.6825

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Copyright: © Tang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — PEA15 induces stem cell-like features of colon cancer cells. (A) Upon upregulation of PEA15, the ability of spheroid formation of SW-480 cells and RKO cells was enhanced. In contrast, the ability of spheroid formation of both cells weakened after PEA15 downregulation. (B) The high expression of PEA15 in colorectal cancer cells exhibited more of EPCAM⁺ and CD133⁺. (C) The proportion of SP in RKO cells decreased after PEA15 downregulation, whereas the proportion of SP increased in SW-480 cells after PEA15 upregulation. **P<0.01 and ***P<0.001 compared to controls.