ACD |
Anemia of chronic disease |
ALK |
Anaplastic lymphoma kinase |
AR |
Adrenergic receptor |
Bcr-Abl |
Break point cluster-Abelson |
Btk |
Bruton’s tyrosine kinasel |
CD |
Crohn’s disease |
CDK |
Cyclin-dependent kinase |
CHK |
Checkpoint kinase |
DCE |
1,2-Dichloroethane |
DDQ |
2,3-Dicyano-5,6-dichlorobenzoquinone |
DFT |
Density functional theory |
DMPK |
Drug metabolism and pharmacokinetics |
DMPU |
1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone |
DMSO |
Dimethyl sulfoxide |
EGFR |
Epidermal growth factor receptor |
ER |
Endoplasmic reticulum |
ERK |
Extracellular signal-regulated kinase |
EZH |
Enhancer of zeste homologue |
FBLD |
Fragment-based lead discovery |
FDA |
Food and drug administration |
FGFR |
Fibroblast growth factor receptor |
FRET |
Forster resonance energy transfer |
FLT3 |
Fms-like tyrosine kinase 3 |
FtsZ |
Filamentous temperature-sensitive protein Z |
GK |
Glucokinase |
GPR |
G-protein coupled receptor |
GR |
Glucocorticoid receptor |
GRAs |
Glucagon receptor antagonists |
GRK |
G protein-coupled receptor kinase |
GSK3β |
Glycogen synthase kinase 3 betas |
hCAs |
Human carbonic anhydrases |
HDACs |
Histone deacetylases |
hEGR |
Human ether-a-go-go related gene |
hFOB |
Human fetal osteoblasts |
HFIP |
Hexafluoroisopropanol |
HT |
Hydroxytryptamine |
HTS |
High-throughput screening |
HUVEC |
Human umbilical vein endothelial cells |
IDO |
Indoleamine-pyrrole 2,3-dioxygenase |
IKKβ |
Inhibitor of nuclear factor kappa-B kinase betan |
JAK |
Janus kinase |
LE |
Excellent ligand |
LPS |
Lipopolysaccharide |
LRRK |
Leucine-rich repeat kinase |
MA |
Molecular sieves |
MAC |
Membrane attack complex |
MBA |
Methoxybenzamide |
MCHR |
Melanin-concentrating hormone receptor |
MIC |
Minimum inhibitory concentration |
NMT |
N-myristoyltransferase |
NMR |
Nuclear magnetic resonance |
NOD |
Nucleotide-binding oligomerization domain-containing protein |
NSCLC |
Non-small cell lung cancer |
OGTT |
Oral glucose tolerance test |
OPG |
Osteoprotegerin |
PAD |
Protein arginine deiminase |
PD |
Pharmacodynamic |
PDGFRβ |
Platelet-derived growth factor receptor betan |
PDK |
Phosphoinositide-dependent kinase |
PEC |
Posterior eye cup |
PI3Kδ |
Phosphoinositide 3-kinase deltae |
PIFA |
[Bis-(trifluoroacetoxy)iodo]benzene |
PK |
Pharmacokinetic |
PKC |
Protein kinase C |
PLK4 |
Polo-like kinase 4 |
RET |
Rearranged during transfection |
RIP |
Receptor-interacting protein |
ROCK |
Rho-associated coiled-coil kinase |
SAHA |
Suberoylanilide hydroxamic acid |
SAR |
Structure-activity relationship |
SCW |
Streptococcal cell wall |
SEDRs |
Selective estrogen receptor degraders |
SGRMs |
Selective glucocorticoid receptor modulators |
SNAr |
Nucleophilic aromatic substitution |
TA |
Transactivation |
TAT |
Tyrosine aminotransferase |
TGI |
Tumor growth inhibition |
TNFα |
Tumor necrosis factor-alphas |
TTK |
Tyrosine threonine kinase |
TR |
Transrepression |
TRPA |
Transient receptor potential ankyrin-repeat |
UC |
Ulcerative colitis |
ULK |
Unc-51-like kinase |
USP |
Ubiquitin specific protease |
VEGFR |
Vascular endothelial growth factor receptor |