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. 2018 Oct 27;23(11):2789. doi: 10.3390/molecules23112789

Figure 3.

Figure 3

(A) Structure of the 3’ end of MALAT1 reveals a triple helix with the 3’ end sequestered in a U-A-U base triple, protecting the 3’ end from nucleolytic degradation (B) MALAT1 sequesters the negative regulator DBC1, releasing the deacetylase SIRT1 to activate p53 for transactivation.