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. 2018 Nov 1;23(11):2837. doi: 10.3390/molecules23112837

Figure 2.

Figure 2

Effect of Cnidii Monnieris Fructus extract on the uptake of uric acid via URAT1. (a) HEK293/PDZK1 cells were transiently transfected with human URAT1. Cells were incubated with uric acid (11.6 µM) with or without the extract at 37 °C for 30 min, and the uptakes of uric acid into the cells were measured. Data are expressed as the mean ± S.E. (n = 3). (b) Cytotoxicity of Cnidii Monnieris Fructus extract was measured using the MTT method. Data are expressed as the mean ± S.E. (n = 6). Benzbromarone (BZ, 50 µM) was used as a positive control. *** p < 0.001 vs. the control group by analysis of variance (ANOVA) and Bonferroni–Dunnett’s multiple t-test.