Table 2.
Half maximal inhibitory concentration (IC50) values of the cytotoxic activity of the essential oil (EO) from the leaves of Croton matourensis.
| Cell Lines | Origin | Histological Type | IC50 in µg/mL | |
|---|---|---|---|---|
| EO | DOX | |||
| Cancer cells | ||||
| MCF-7 | Human | Breast adenocarcinoma | 23.3 18.2–29.7 |
0.3 0.2–0.4 |
| HCT116 | Human | Colon carcinoma | 28.9 22.1–37.8 |
0.1 0.1–0.2 |
| HepG2 | Human | Hepatocellular carcinoma | 28.5 17.1–37.3 |
0.03 0.01–0.2 |
| HL-60 | Human | Promyelocytic leukemia | 17.8 14.6–21.7 |
0.04 0.02–0.08 |
| Non-cancer cell | ||||
| MRC-5 | Human | Lung fibroblast | 25.8 22.0–30.4 |
0.2 0.1–0.5 |
Data are presented as IC50 values, in μg/mL, with respective 95% confidence interval obtained by nonlinear regression from at least three independent experiments performed in duplicate, measured by Alamar blue assay after 72 h of treatment. Doxorubicin (DOX) was used as the positive control.