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. 2018 Oct 29;41(1):213–223. doi: 10.3892/or.2018.6828

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Copyright: © Yu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — UDCA increases intracellular ROS levels and induces ΔΨm collapse in M14 cells (A) M14 cells were incubated with UDCA. The changes of the ROS level were examined by flow cytometry. (B) Cells were treated with UDCA. Changes in ΔΨm were examined by flow cytometry. (C) The quantification of intracellular ROS levels of cells. (D) The quantification of mitochondrial depolarization. One representative experiment out of three is presented. *P<0.05, **P<0.01 as compared with the control group. UDCA, ursodeoxycholic acid; ROS, reactive oxygen species; ΔΨm, mitochondrial membrane potential.