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. 2018 Oct 29;41(1):213–223. doi: 10.3892/or.2018.6828

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Copyright: © Yu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — Western blotting results and the illustration of apoptotic signaling induced by UDCA in human melanoma M14 cells. (A-D) Western blotting results of M14 cell protein changes following treatment with UDCA. (E) Western blotting results of M14 cell cytosol protein changes following treating with UDCA. (F) Signaling pathway of apoptosis of M14 cells induced by UDCA. UDCA, ursodeoxycholic acid; CDK, cyclin-dependent kinase; MMP, matrix metalloproteinase; PARP, poly (ADP-ribose) polymerase; Apaf, apoptotic protease activating factor; Bcl-2. B cell lymphoma-2; Bax, Bcl-2 associated × protein; ROS, reactive oxygen species, ΔΨm, mitochondrial membrane potential.