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. 2018 Oct 17;41(1):77–86. doi: 10.3892/or.2018.6803

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Western blot analysis of the effect of osimertinib combined with IR on EGFR phosphorylation levels in vitro. Cells were treated with osimertinib 1 h prior to IR, and cell proteins were collected 2 h following IR treatments. GAPDH was included as a loading control. (A) Western blot analysis. (B-E) Quantitative analysis of changes in (B) p-EGFR (1068), (C) p-EGFR (1173), (D) p-AKT and (E) p-ERK, respectively. *P<0.05 vs. IR alone; ^#P<0.05 vs. DMSO control. IR, irradiation; DMSO, dimethyl sulfoxide; p-, phosphorylated; EGFR, epidermal growth factor receptor; AKT, protein kinase B; ERK, extracellular signal-regulated kinase.

Figure 4. — Western blot analysis of the effect of osimertinib combined with IR on EGFR phosphorylation levels in vitro. Cells were treated with osimertinib 1 h prior to IR, and cell proteins were collected 2 h following IR treatments. GAPDH was included as a loading control. (A) Western blot analysis. (B-E) Quantitative analysis of changes in (B) p-EGFR (1068), (C) p-EGFR (1173), (D) p-AKT and (E) p-ERK, respectively. *P<0.05 vs. IR alone; ^#P<0.05 vs. DMSO control. IR, irradiation; DMSO, dimethyl sulfoxide; p-, phosphorylated; EGFR, epidermal growth factor receptor; AKT, protein kinase B; ERK, extracellular signal-regulated kinase.