Scheme 1.
Reagents and conditions: i–Ca(OCl)2, CO2, DCM/H2O, 0 °C; ii—NaN3, MeCN or DMSO; iii—3-bromoprop-1-yne, EtOH or MeCN, base; iv—Et3N, CuBr or CuI (5 mol%), MeCN or DMSO, 60 °C.
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