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AKR1B10 selectivity of the α-acid-mixture and its isolated compounds expressed as IC50-ratios of AKR1A1/AKR1B10 and AKR1B1/AKR1B10.
| Compounds | Ratio AKR1A1/AKR1B10 | Ratio AKR1B1/AKR1B10 |
|---|---|---|
| α-acid mixture | 115 | 137 |
| Compound 1 | ≥19 | >23 |
| Compound 2 | >74 | >93 |
| Compound 3 | >52 | >64 |
