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IC50 and Ki values of AKR1B10 mediated farnesal reduction with isolated hop-compounds. IC50 and Ki values are presented as mean ± SD of at least three experiments.
| Enzyme | AKR1B10 | ||
|---|---|---|---|
| Substrate | Farnesal [5 µM] | Mode of inhibition | |
| Parameter | IC50 | Ki | |
| Compound 1 | 29.27 ± 1.53 µM | 16.79 ± 1.33 µM | competitive |
| Compound 2 | 29.78 ± 1.72 µM | 16.53 ± 1.74 µM | non-competitive |
| Compound 3 | 7.78 ± 0.43 µM | 3.94 ± 0.33 µM | non-competitive |
